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Urine Toxic & Essential Elements


Urine Toxic & Essential Elements

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Product Description

Urine Toxic & Essential Elements


Urine Collection & Return Instructions

Labs Frequently Asked Questions

Sample Report 


Urine Elements are traditionally used to evaluate exposure to potentially toxic elements and wasting of nutrient elements. Additionally, the comparison of urine element concentrations before and after administration of a chelator can be used to estimate net retention of potentially toxic elements. Subsequent urine element analyses, also following the administration of a chelator, are useful for monitoring the efficacy of metal detoxification therapy. Results are expressed per 24 hours or creatinine corrected to account for urine dilution effects.

This test is useful for

  • Toxic Element Exposure
  • Alopecia
  • Bone Density
  • Cardiovascular Disease
  • Depression
  • Dermatitis or Poor Wound Healing
  • Detoxifiction Therapy
  • Fatigue
  • Gastrointestinal Symptoms
  • Hypertension
  • Immune Function
  • Impaired Glucose Tolerance
  • Inflammation
  • Kidney Function
  • Nutritional Deficiencies
  • Parkinson's-like Symptoms


Detailed Information

Analysis of the levels of toxic metals in urine after the administration of a metal detoxification agent is an objective way to evaluate the accumulation of toxic metals. Acute metal poisoning is rare. More common, however, is a chronic, low-level exposure to toxic metals that can result in significant retention in the body that can be associated with a vast array of adverse health effects and chronic disease. 

One cannot draw valid conclusions about adverse health effects of metals without assessing net retention. For an individual, toxicity occurs when net retention exceeds physiological tolerance. Net retention is determined by the difference between the rates of assimilation and excretion of metals. To evaluate net retention, one compares the levels of metals in urine before and after the administration of a pharmaceutical metal detoxification agent such as EDTA, DMSA or DMPS. Different compounds have different affinities for specific metals, but all function by sequestering "hidden" metals from deep tissue stores and mobilizing the metals to the kidneys for excretion in the urine. 

It is important to perform both pre- and post-provocation urinalysis to permit distinction between ongoing exposures to metals (pre-) and net bodily retention. The pre-provocation urine collection can also be utilized to assess the rate of creatinine clearance if a serum specimen is also submitted.

Many clinicians also request the analysis of essential elements in urine specimens to evaluate nutritional status and the efficacy of mineral supplementation during metal detoxification therapy. Metal detoxification agents can significantly increase the excretion of specific nutrient elements such as zinc, copper, manganese and molybdenum. 

Chromium metabolism authorities suggest that 24-hour chromium excretion likely provides the best assessment of chromium status. Early indication of renal dysfunction can be gleaned from urinary wasting of essential elements such as magnesium, calcium, potassium and sodium in an unprovoked specimen.

Variability in urine volume can drastically affect the concentration of elements. To compensate for urine dilution variation, elements are expressed per unit creatinine for timed collections. For 24-hour collections, elements are reported as both units per 24 hours and units per creatinine.

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.

AnalyteCPTABN Required
Aluminum; urine 82108 Yes
Antimony; urine 83018 Yes
Arsenic; urine 82175 Yes
Barium; urine 83018 Yes
Beryllium; urine 83018 Yes
Bismuth; urine 83018 Yes
Boron; urine 83018 Yes
Cadmium; urine 82300 Yes
Calcium; urine 83018 Yes
Cesium; urine 83018 Yes
Chromium; urine 82495 Yes
Cobalt; urine 83018 Yes
Copper; urine 82525 Yes
Gadolinium; urine 83018 Yes
Iron; urine 83540 Yes
Lead; urine 83655 Yes
Lithium; urine 80178 Yes
Magnesium; urine 83735 Yes
Manganese; urine 83785 Yes
Mercury; urine 83825 Yes
Molybdenum; urine 83018 Yes
Nickel; urine 83885 Yes
Palladium; urine 83018 Yes
Phosphorus; urine 84105 Yes
Platinum; urine 83018 Yes
Potassium; urine 84133 Yes
Selenium; urine 84255 Yes
Sodium; urine 84300 Yes
Strontium; urine 83018 Yes
Sulfur; urine 84999 Yes
Tellurium; urine 83018 Yes
Thallium; urine 83018 Yes
Thorium; urine 83018 Yes
Tin; urine 83018 Yes
Tungsten; urine 83018 Yes
Uranium; urine 83018 Yes
Vanadium; urine 83018 Yes
Zinc; urine 84630 Yes

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